The pathogenesis of scleroderma

Systemic sclerosis (SSc) results from the complex interplay between the immune system, vasculature and tissue-repair mechanisms.Endothelial injury is the prime event; environmental triggers in the susceptible individual trigger the pathologic process, which translates into fibrosis.The outcome of SSc is not Baby Book as bleak as it looked a couple of decades ago.With a greater understanding Foundations of older pathways, as well as elucidation of newer ones, the potential targets to block and even reverse fibrosis bring around a revolution in the way we look at this once dreaded disease.